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Contraindicated (one)pentobarbital will lower the extent or impact of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the formation and elimination of cariprazine's Lively metabolites.pentobarbital will lower the level or effect of trazodone by influencing hepatic/intestinal enzyme CYP